General Clinical Chemistry Analyzers and Accessories
Abcam SIS3, Smad3 inhibitor, 5MG
MW 490 Da, Purity >98%. Potent and selective Smad3 inhibitor. Selectively inhibits TGF-beta 1/ALK5-induced Smad3 phosphorylation. Inhibits the TGF-beta 1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site. Has no effect on Smad2, p38, MAPK, ERK or PI 3-kinase signaling.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GW 6471, PPAR alpha antagonist, 5MG
MW 619.7 Da, Purity >98%. Potent PPAR alpha antagonist (IC₅₀ = 240 nM). Drives displacement of co-activators from PPAR alpha. Promotes recruitment of co-repressor proteins SMRT and NCoR to ligand binding domain. Inhibits cardiomyocyte differentiation in mouse embryonic stem cells. Causes reduced expression of cardiac sarcomeric proteins and specific genes in a time-dependent manner.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LMK 235, HDAC inhibitor, 25MG
MW 294.35 Da, Purity >98%. Highly potent and selective HDAC inhibitor. Greater potency for HDAC4 and HDAC5 (IC₅₀ = 11.9 and 4.2 nM, respectively) than other HDAC family members (IC₅₀ values = HDAC1 320 nM, HDAC2 881 nM, HDAC6 55.7 nM, and HDAC8 1278 nM. Demonstrates inhibitor activity in human ovarian cell lines (IC₅₀ =0.49μM) and cisplatin resistant cell lines (IC₅₀ = 0.32μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Daclatasvir (BMS-790052), HCV NS5A protein inhibitor, 50MG
MW 738.9 Da, Purity =97%. Daclatasvir a potent, direct acting, small molecule inhbitor of HCV NS5A protein. It inhbibits replicons expressing a wide range of HCV genotypes with EC₅₀ values in the pM range (9 and 71 pM against the 1b and 2a genotypes, respectively). It also inhibits infection by the JFH-1 genotype 2a virus in cultured cells. Daclatasvir is thought to inhibit relication of the HCV viral genome by affecting the subcellular localization of HCV NS5A and preventing its incorporation into relication complexes. In HCV-infected Huh7 cells, Daclatasvir (1 nM) inhibits viral RNA synthesis and viron assembly. Daclatasvir displays moderate activity against the OAT1B1 (IC₅₀ = 1.5 μM) and OAT1B3 (IC₅₀ = 3.27 μM) organic anion transporters.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Tetracaine
Chemical. CAS 94-24-6. Formula C15H24N2O. MW 264.36. Synthetic. Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2 from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine ACh receptors nAChRs.
AdipoGen Tetracaine hydrochloride
Chemical. CAS 136-47-0. Formula C15H24N2O2 . HCl. MW 264.4 . 36.5. Synthetic. Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2 from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine ACh receptors nAChRs.
AdipoGen Tetrakistrimethylsilylsilane
Chemical. CAS 4098-98-0. Formula CH33Si4Si. MW BD9837. Tetrakistrimethylsilylsilane TTMSS is an organosilicon compound. TTMSS is widely used as a reagent and precursor in organic synthesis and silicon-based chemistry. TTMSS is commonly used as a protecting group for various functional groups in organic synthesis, in deoxygenation reactions to remove oxygen-containing functional groups like ketones, aldehydes, and esters, converting them into the corresponding trimethylsilyl ethers. TTMSS is utilized in silylation reactions to introduce trimethylsilyl groups onto organic compounds, enhancing their volatility and stability for gas chromatography and mass spectrometry analysis. Due to its diverse applications in organic chemistry, Tetrakistrimethylsilylsilane has become a valuable tool for synthetic chemists, particularly in the fields of silicon-based chemistry, protecting group strategies, and cross-coupling reactions.
AdipoGen C14-L-HSL
Chemical. CAS 202284-87-5. Formula C18H33NO3. MW 311.5. Synthetic. N-Tetradecanoyl-L-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones AHL are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms. It appears later than shorter acyl chain AHLs in developing biofilms and, like other long chain AHLs, stimulates bacterial growth. C14-HSL also alters the proteolytic activity and enhances the migration of some strains of Proteus mirabilis. Induces violacein expression in a Chromobacterium violaceum mutant usually not able to produce homoserine lactones.
AdipoGen Simetone
Chemical. CAS 673-04-1. Formula C8H15N5O. MW 197.3. Synthetic. Triazine herbicide. Mode of action through inhibition of photosynthesis at photosystem II. Compound can be used as analytical reference material.
AdipoGen TrisDEAcyclopropenylium trif
Chemical. CAS 1333477-58-9. Formula C17H30F6N4O4S2. MW 532.56. Synthetic Air- and water-stable ionic liquid. The properties of these ionic liquids include almost zero vapour pressure, low flammability and ease of recycling. They are frequently considered as potential green alternatives to classical organic solvents. Additionally, most classes can be readily tuned to provide unique solvent environments in which to carry out reactions, extractions and other processes. There are a large number of applications.
AdipoGen Triaziflam
Chemical. CAS 131475-57-5. Formula C17H24FN5O. MW 333.4. Synthetic. Triazine herbicide. Mode of action is involves the inhibition of the photosystem II electron transport, as well as the inhibition of cellulose biosynthesis. Compound can be used as analytical reference material.
AdipoGen Thiamethoxam
Chemical. CAS 153719-23-4. Formula C8H10ClN5O3S. MW 291.71. Thiamethoxam is a broad-spectrum, systemic neonicotinoid insecticide, which means it is absorbed quickly by plants and transported to all of its parts, including pollen, where it acts to deter insect feeding. The compound gets in the way of information transfer between nerve cells by interfering with nicotinic acetylcholine receptors in the central nervous system, and eventually paralyzes the muscles of the insects. Compound can be used as analytical reference material.
AdipoGen Sulfluramid
Chemical. CAS 4151-50-2. Formula C10H6F17NO2S. MW 527.2. Synthetic. Perfluorinated delayed-action insecticide/pesticide. Mode of action is by uncoupling oxidative phosphorylation via disruption of the proton gradient. Suppresses immunoglobulin Ig M production in mice. Shown to be cytotoxic. Compound can be used as analytical reference material.
AdipoGen Rhodamine 6G hexanediamine ami
Chemical. CAS 1140505-40-3. Formula C32H40N4O2 . C4H2F6O4. MW 740.73. Synthetic. N-6-Aminohexylrhodamine 6G-amide bistrifluoroacetate is a rhodamine 6G-amide derivative useful as a bioreagent in fluorescence assays.
AdipoGen Perfluorhexane mixed isomers
Chemical. CAS 355-42-0. Formula C6F14. MW 338.04. Used as a building block or intermediate for synthesis perfluorohexane plays a vital role as a reaction medium, especially for photooxidation reactions. Perfluorohexane is used as a coolant, photosensitizer in fluorous biphasic singlet oxygenation and an inert reaction medium. It is used in the electronic cooling liquid and insulator. Further, it finds application as an ultrasound contrast agent.